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An F5 tornado is in category five of the Fujita scale, the deadliest ranking for a tornado. The wind speed range of this phenomena is 261-318 miles per hour. Tornadoes of this strength can lift well-constructed houses off their foundations, strip the bark off of trees, and fling objects over 300 ft. The most deadly tornado in the US was the Tri-State Tornado on march 18, 1925, in Missouri.
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http://scopeweb.mit.edu/wp-content/uploads/2008/03/800px-hurricane_rita_peak.jpg
Information Sources:
http://www.tornadoproject.com/fscale/fscale.htm
http://www.crh.noaa.gov/dtx/1953beecher/
http://www.tornadoproject.com/toptens/1.htm#top